Aprepitant
Sold as Entager, Arenta, Gomesis, Aprepitant eurolab, Aprepitant combipack eurolab, Vomend, Prepix, Apemeze, Aprepitant equity, Emend
3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,4-dihydro-1,2,4-triazol-5-one
Drag to rotate. Structure from PubChem CID 135413536.
Background
Registration
- Applicants
- 7
- Registrations
- 19
- Schedule source
- Consolidated Schedules 06 July 2026
Applicants and registrations
| Applicant | Brands | Dosages | Registrations | Schedule | Leaflets |
|---|---|---|---|---|---|
| Abex Pharmaceutica (Pty) LtdCancelled | Entager | 80, 125 | 520816, 520817 | S4 | None |
| Astral Pharma (Pty) Ltd | Arenta | 80, 125 | 520819.816, 520820.817 | S4 | None |
| Austell Pharmaceuticals (Pty) Ltd | Gomesis | 80 mg, 125 mg | 530084, 530085 | S4 | None |
| Eurolab (Pty) Ltd | Aprepitant eurolab, Aprepitant combipack eurolab, Apemeze | 80 mg, 125 mg | 530234, 530235, 530236, 560062, 560063 | S4 | None |
| Adcock ingram limited | Vomend, Prepix | 80, 125 | 530445, 530446, 530448.445, 530449.446 | S4 | None |
| Equity Pharmaceutical (Pty) Ltd | Aprepitant equity | 80, 125 | 580147, 580148 | S4 | None |
| Msd (Pty) Ltd | Emend | 80, 125 | A380626, A380627 | S4 | PIPIL |
Variants
| Product | Strength and form | Registration | Status | Schedule | Leaflets |
|---|---|---|---|---|---|
| Entager 80 EACH CAPSULE CONTAINS: APREPITANT 80,0 mg | 80 | 52081652/5.7.2/0816 | Cancelled | S4 | None |
| Entager 125 EACH CAPSULE CONTAINS: APREPITANT 125,0 mg | 125 | 52081752/5.7.2/0817 | Cancelled | S4 | None |
| Arenta 80 Each Capsule contains: Aprepitant 80,0 mg | 80 | 520819.81652/5.7.2/0819.816 | Registered | S4 | None |
| Arenta 125 Each Capsule contains: Aprepitant 125,0 mg | 125 | 520820.81752/5.7.2/0820.817 | Registered | S4 | None |
| Gomesis 80 MG capsules EACH CAPSULE CONTAINS: APREPITANT 80,0 mg | 80 mgCapsules | 53008453/5.7.2/0084 | Registered | S4 | None |
| Gomesis 125 MG capsules EACH CAPSULE CONTAINS: APREPITANT 125,0 mg | 125 mgCapsules | 53008553/5.7.2/0085 | Registered | S4 | None |
| Aprepitant 80 eurolab EACH CAPSULE CONTAINS: APREPITANT 80,0 mg | 80 | 53023453/5.7.2/0234 | Registered | S4 | None |
| Aprepitant 125 eurolab EACH CAPSULE CONTAINS: APREPITANT 125,0 mg | 125 | 53023553/5.7.2/0235 | Registered | S4 | None |
| Aprepitant combipack eurolab EACH CAPSULE CONTAINS: APREPITANT 80,0 mg or 125,0 mg | Not listed | 53023653/5.7.2/0236 | Registered | S4 | None |
| Vomend 80 EACH CAPSULE CONTAINS APREPITANT 80,0 mg | 80 | 53044553/5.7.2/0445 | Registered | S4 | None |
| Vomend 125 EACH CAPSULE CONTAINS APREPITANT 125,0 mg | 125 | 53044653/5.7.2/0446 | Registered | S4 | None |
| Prepix 80 EACH CAPSULE CONTAINS APREPITANT 80,0 mg | 80 | 530448.44553/5.7.2/0448.445 | Registered | S4 | None |
| Prepix 125 EACH CAPSULE CONTAINS APREPITANT 125,0 mg | 125 | 530449.44653/5.7.2/0449.446 | Registered | S4 | None |
| Apemeze 80 MG EACH CAPSULE CONTAINS APREPITANT 80,0 mg | 80 mg | 56006256/5.7.2/0062 | Registered | S4 | None |
| Apemeze 125 MG EACH CAPSULE CONTAINS APREPITANT 125,0 mg | 125 mg | 56006356/5.7.2/0063 | Registered | S4 | None |
| Aprepitant 80 equity EACH CAPSULE CONTAINS: APREPITANT 80,0 mg | 80 | 58014758/5.7.2/0147 | Registered | S4 | None |
| Aprepitant 125 equity EACH CAPSULE CONTAINS: APREPITANT 125,0 mg | 125 | 58014858/5.7.2/0148 3 | Registered | S4 | None |
| Emend 80 EACH CAPSULE CONTAINS APREPITANT 80,0 mg | 80Capsules and combipack | A380626A38/5.7.2/0626Approved 10 June 2016 | Registered | S4 | PIPIL |
| Emend 125 EACH CAPSULE CONTAINS APREPITANT 125,0 mg | 125Capsules and combipack | A380627A38/5.7.2/0627Approved 10 June 2016 | Registered | S4 | PIPIL |
Regulatory status
Where S4 sits on the scale
Prescription-only medicine.
Schedule 4 covers most ordinary prescription medicines. You need a prescription from an authorised prescriber, such as a doctor or dentist, and a pharmacist dispenses it. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S4, matched to the Consolidated Schedules by ingredient, confidence high.
Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Consolidated Schedules listings for Aprepitant
S4: Aprepitant
Consolidated Schedules 06 July 2026, line 5335
Pharmacological class: Anti-emetics and antivertigo preparations. (class 5.7.2)
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
SAHPRA documents
These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.