Amiloride, hydrochlorothiazide
Sold as Gsa-retic, Aquadrex, Dezretic, Amiloretic, Amiloretic H.S., Amilco, Adco-retic, Bio-amilco, Betaretic, Merck-amilozide
Combination product
This product contains more than one active ingredient, so it has no single molecular structure.
Background
Registration
- Applicants
- 7
- Registrations
- 10
- Schedule source
- Consolidated Schedules 06 July 2026
Applicants and registrations
| Applicant | Brands | Dosages | Registrations | Schedule | Leaflets |
|---|---|---|---|---|---|
| Adcock ingram limited1 of 4 cancelled | Gsa-retic, Amiloretic, Amiloretic H.S., Adco-retic | 5/50, tablets, 5 mg/50 mg | 280484, L0396, U0040, V0260 | S3 | PIPIL |
| Warner-lambert SA (Pty) LtdCancelled | Aquadrex | Not stated | 280554 | S3 | None |
| Dezzo Trading 392 (Pty) Ltd | Dezretic | Not stated | 280684 | S3 | None |
| The Premier Pharmaceutical Co LtdCancelled | Amilco | Not stated | V0085 | S3 | None |
| Biotech Laboratories (Pty) Ltd | Bio-amilco | Not stated | W0319 | S3 | None |
| Unimed Healthcare (Pty) Ltd | Betaretic | Not stated | Y0058 | S3 | None |
| Merck Generics Rsa (Pty) Ltd | Merck-amilozide | Not stated | Y0133 | S3 | None |
Variants
| Product | Strength and form | Registration | Status | Schedule | Leaflets |
|---|---|---|---|---|---|
| Gsa-retic 5/50 EACH TABLET CONTAINS AMILORIDE HYDROCHLORIDE 5 mg HYDROCHLOROTHIAZIDE 50 mg | 5/50 | 28048428/18.1/0484 | Cancelled | S3 | None |
| Aquadrex* EACH TABLET CONTAINS AMILORIDE HYDROCHLORIDE 5 mg HYDROCHLOROTHIAZIDE 50 mg | Not listed | 28055428/18.1/0554 | Cancelled | S3 | None |
| Dezretic EACH TABLET CONTAINS AMILORIDE HYDROCHLORIDE 5 mg HYDROCHLOROTHIAZIDE 50 mg | Not listed | 28068428/18.1/0684 | Registered | S3 | None |
| Amiloretic EACH TABLET CONTAINS AMILORIDE HYDROCHLORIDE 5 MG HYDROCHLOROTHIAZIDE 50 MG | Not listed | L0396L/18.1/396 | Registered | S3 | None |
| Amiloretic H.S. Tablets EACH TABLET CONTAINS AMILORIDE HYDROCHLORIDE 2,5 MG HYDROCHLOROTHIAZIDE 25 MG | Tablets | U0040U/18.1/40 | Registered | S3 | None |
| Amilco* EACH TABLET CONTAINS AMILORIDE HYDROCHLORIDE 5 mg HYDROCHLOROTHIAZIDE 50 mg | Not listed | V0085V/18.1/85 | Cancelled | S3 | None |
| Adco-retic EACH TABLET CONTAINS AMILORIDE HYDROCHLORIDE 5 mg HYDROCHLOROTHIAZIDE 50 mg | 5 mg/50 mgTablets. | V0260V/18.1/260Approved 13 March 2023 | Registered | S3 | PIPIL |
| Bio-amilco EACH TABLET CONTAINS AMILORIDE HYDROCHLORIDE (ANHYDROUS) EQUIVALENT TO 5 mg AMILORIDE HYDROCHLORIDE HYDROCHLOROTHIAZIDE 50 mg | Not listed | W0319W/18.1/319 | Registered | S3 | None |
| Betaretic EACH TABLET CONTAINS AMILORIDE HYDROCHLORIDE 5 mg HYDROCHLOROTHIAZIDE 50 mg | Not listed | Y0058Y/18.1/58 | Registered | S3 | None |
| Merck-amilozide EACH TABLET CONTAINS AMILORIDE HYDROCHLORIDE 5 mg HYDROCHLOROTHIAZIDE 50 mg | Not listed | Y0133Y/18.1/133 | Registered | S3 | None |
Regulatory status
Where S3 sits on the scale
Needs a doctor's prescription, dispensed by a pharmacist.
Schedule 3 medicines can only be sold on a prescription from an authorised prescriber, such as a doctor or dentist. A pharmacist dispenses the medicine once they have the written prescription, or a verbal instruction from a prescriber they know. Its price, name, pack size and strength can still be told to the public, as long as nothing links it to what it treats.
Schedule S3, matched to the Consolidated Schedules by ingredient, confidence medium.
Who may supply: A pharmacist dispensing against a written or verbal prescription from an authorised prescriber; a veterinarian, who may also prescribe, compound or dispense it directly; a medical practitioner or dentist, who may prescribe it and may compound or dispense it directly only if licensed under section 22C(1)(a); manufacturers and wholesalers may supply people who may lawfully possess it; and, for animal treatment, a person practising a para-veterinary profession, on a veterinarian's written or verbal instruction.
Consolidated Schedules listings for Amiloride hydrochloride, hydrochlorothiazide
S3: Amiloride
Consolidated Schedules 06 July 2026, line 3136
S3: Hydrochlorothiazide
Consolidated Schedules 06 July 2026, line 3721
Pharmacological class: Diuretics. (class 18.1)
This is an informational summary of the Medicines and Related Substances Act 101 of 1965 and its 2017 General Regulations. It is not medical advice and not legal advice. Always check the medicine's label, which carries the schedule number inside a square border, or ask a pharmacist if you are unsure.
SAHPRA documents
These documents are provided by SAHPRA for informational purposes. Always consult with a healthcare professional for medical advice.